Spravato Treatment for Depression

A new option for treatment-resistant depression

For patients who haven’t found relief with traditional antidepressants, Spravato® (esketamine) nasal spray offers a new path forward. At Breakthrough HQ, our team provides this FDA-approved treatment in a safe, supportive environment designed to maximize comfort and healing.

What to Expect

  • Number 1

    Initial Consultation

    (60 minutes)

    We begin with a comprehensive psychiatric evaluation to confirm whether Spravato is appropriate for you. Together, we’ll review your history, prior treatments, and treatment goals.

  • Number 2

    Treatment Sessions

    (2 hours each)

    Spravato treatments take place in our office under direct supervision. Each session lasts about two hours to allow for administration, monitoring, and recovery before you go home.

  • Number 3

    Ongoing Monitoring

    (30 minutes)

    We will meet for 30-minute follow-up appointments after week 1, then at the end of months 1, 2, and 3. Once you are in the maintenance phase (after month 3), follow-up frequency is determined on a case-by-case basis, guided by your response, tolerability, and clinical progress.

Conditions Treated with Spravato

  • Treatment-resistant depression (TRD) in adults

  • Major depressive disorder with suicidal thoughts or actions (MDD with SI)

Why Choose
Breakthrough HQ

  • A comfortable, stigma-free environment designed with patient experience in mind

  • Continuous monitoring for safety during every session

  • Collaboration with your care team for comprehensive support

  • Providers who specialize in psychiatric medication management and depression treatment

Spravato can only be given in certified treatment centers like ours, where patients are carefully monitored during each visit. Every dose is administered under medical supervision, and you’ll stay in the office for observation before going home.

Frequently Asked Questions

  • Spravato works on a different brain pathway (the glutamate system) than standard antidepressants, which may help when other medications haven’t.

  • Treatment usually begins twice a week for four weeks, then tapers to once a week for the next four weeks. After that, sessions continue either weekly or every other week on an ongoing basis, depending on your progress.

  • Coverage varies by plan. Our team can help determine your benefits and discuss financial options.

  • Our general age range is 6 to 64. Each provider has their own specialty within that range, so not all providers see every age group. The easiest way to check is by viewing provider profiles on our booking page or by reaching out to our office, and we’ll make sure you’re scheduled with the right provider for your needs.

  • No. Because Spravato may cause temporary drowsiness or dizziness, you cannot drive until the next day. Please arrange a safe ride home after each session.

Take the Next Step

If you’re struggling with depression that hasn’t improved with other treatments, Spravato may be an option.